Article
Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast.
Cell - 28 May 1999
Martin S G, Laroche T, Suka N, Grunstein M, Gasser S M
Abstract excerpt
Telomeric TG-rich repeats and their associated proteins protect the termini of eukaryotic chromosomes from end-to-end fusions. Associated with the cap structure at yeast telomeres is a subtelomeric domain of heterochromatin, containing the silent information regulator (SIR) complex. The Ku70/80 heterodimer (yKu) is associated both with the chromosome end and with subtelomeric chromatin. Surprisingly, both yKu and...
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