Article
Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis.
The Journal of biological chemistry - 19 Apr 2002
Mukai Jun, Shoji Shisako, Kimura Makoto T, Okubo Shuichi, Sano Hajime, Suvanto Petro, Li Yin, Irie Shinji, Sato Taka-Aki
Abstract excerpt
Nerve growth factor (NGF) can induce apoptosis in neural cells via activation of the low affinity neurotrophin receptor p75NTR. NADE (p75NTR-associated cell death executor) is a p75NTR-associated protein that mediates apoptosis in response to NGF by interacting with the death domain of p75NTR in 293T, PC12, and nnr5 cells (Mukai, J., Hachiya, T., Shoji-Hoshino, S., Kimura, M. T., Nadano, D., Suvanto, P., Hanaoka,...
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