Article
Nur77 transcription activity correlates with its apoptotic function in vivo.
European journal of immunology - 1 Nov 1999
Kuang A A, Cado D, Winoto A
Abstract excerpt
Nur77 is a transcription factor that is induced to a high level during TCR-mediated apoptosis of thymocytes and T cell hybridomas. Expression of a dominant-negative mutant of Nur77 can inhibit TCR-mediated apoptosis, while constitutive expression of full-length Nur77 in thymocytes leads to massive apoptosis. Nur77 is similar to the steroid receptor family and consists of a transactivation, a DNA-binding and a...
Topics
- Animals
- Apoptosis
- DNA-Binding Proteins
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Mice, Transgenic
- Nuclear Receptor Subfamily 4, Group A, Member 1
- Phenotype
- Receptors, Cytoplasmic and Nuclear
- Receptors, Steroid
- Sequence Deletion
- T-Lymphocytes
- Transcription Factors
- Transcription, Genetic
- Transgenes