Nur77 transcription activity correlates with its apoptotic function in vivo.

Abstract excerpt

Nur77 is a transcription factor that is induced to a high level during TCR-mediated apoptosis of thymocytes and T cell hybridomas. Expression of a dominant-negative mutant of Nur77 can inhibit TCR-mediated apoptosis, while constitutive expression of full-length Nur77 in thymocytes leads to massive apoptosis. Nur77 is similar to the steroid receptor family and consists of a transactivation, a DNA-binding and a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Apoptosis
• Share to Mice, Inbred CBA
• Share to Mice, Transgenic