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Article

Dependence receptor UNC5D mediates nerve growth factor depletion–induced neuroblastoma regression

16 Jun 2013

Abstract excerpt

Spontaneous regression of neuroblastoma (NB) resembles the developmentally regulated programmed cell death (PCD) of sympathetic neurons. Regressing tumor cells express high levels of the nerve growth factor (NGF) receptors TRKA and p75NTR and are dependent on NGF for survival; however, the underlying molecular mechanism remains elusive. Here, we show that UNC5D, a dependence receptor that is directly targeted by...

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PMID: 23778138
DOI: 10.1172/jci65988

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