Article
Assessing the role of endooligopeptidase activity of Ndel1 (nuclear-distribution gene E homolog like-1) in neurite outgrowth.
Molecular and cellular neurosciences - 1 Aug 2010
Hayashi Mirian A F, Guerreiro Juliano R, Charych Erik, Kamiya Atsushi, Barbosa Rosicler L, Machado Maurício F, Campeiro Joana D, Oliveira Vitor, Sawa Akira, Camargo Antonio C M, Brandon Nicholas J
Abstract excerpt
Ndel1 plays multiple roles in neuronal development but it is unknown whether its reported cysteine protease activity is important for these processes. Ndel1 is known to be critical for neurite outgrowth in PC12 cells where it works co-operatively in a complex with DISC1 to allow normal neuritogenesis. Through an initial interest in understanding the regulation of the expression of Ndel1 during neuronal...
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