Article
Neurotrophin dependence domain: a domain required for the mediation of apoptosis by the p75 neurotrophin receptor.
Journal of molecular neuroscience : MN - 1 Dec 2000
Rabizadeh S, Ye X, Sperandio S, Wang J J, Ellerby H M, Ellerby L M, Giza C, Andrusiak R L, Frankowski H, Yaron Y, Moayeri N N, Rovelli G, Evans C J, Butcher L L, Nolan G P, Assa-Munt N, Bredesen D E
Abstract excerpt
The mechanisms underlying neurotrophin dependence, and cellular dependent states in general, are unknown. We show that a 29 amino acid region in the intracellular domain of the common neurotrophin receptor, p75NTR, is required for the mediation of apoptosis by p75NTR. Furthermore, contrary to results obtained with Fas, monomeric p75NTR is required for apoptosis induction, whereas multimerization inhibits the...
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