Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm.

The Journal of biological chemistry - 13 Oct 2000

Taniguchi N, Taniura H, Niinobe M, Takayama C, Tominaga-Yoshino K, Ogura A, Yoshikawa K

Abstract excerpt

Necdin, a growth suppressor expressed predominantly in postmitotic neurons, interacts with viral oncoproteins and cellular transcription factors E2F1 and p53. In search of other cellular targets of necdin, we screened cDNA libraries from neurally differentiated murine embryonal carcinoma P19 cells and adult rat brain by the yeast two-hybrid assay. We isolated cDNAs encoding partial sequences of mouse NEFA and rat...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caffeine
Share to Calcium-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to EF Hand Motifs

Share to Growth Substances

Share to Leucine Zippers

Share to Microscopy, Immunoelectron

Share to Nuclear Envelope

Share to Two-Hybrid System Techniques

Source

Identifiers

PMID: 10915798
DOI: 10.1074/jbc.M005103200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm.PMID 10915798Read ↗

Functional domains of necdin for protein-protein interaction, nuclear matrix targeting, and cell growth suppression.Semantic proximity Read ↗

A visual screen of a GFP-fusion library identifies a new type of nuclear envelope membrane protein.Semantic proximity Read ↗

Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteins.Semantic proximity Read ↗

Neuronal vulnerability of CLN3 deletion to calcium-induced cytotoxicity is mediated by calsenilinSemantic proximity Read ↗

Downstream regulatory element antagonist modulator regulates Ca2+ homeostasis and viability in cerebellar neurons.Semantic proximity Read ↗

Necdin, a Prader-Willi syndrome candidate gene, regulates gonadotropin-releasing hormone neurons during developmentSemantic proximity Read ↗

Dependence receptor UNC5D mediates nerve growth factor depletion–induced neuroblastoma regressionSemantic proximity Read ↗

Opposing roles in neurite growth control by two seven-pass transmembrane cadherins.Semantic proximity Read ↗

Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons.Semantic proximity Read ↗

Loss of the Prader-Willi syndrome protein necdin causes defective migration, axonal outgrowth, and survival of embryonic sympathetic neurons.Semantic proximity Read ↗

Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis.Semantic proximity Read ↗

NRAGE, a p75NTR adaptor protein, is required for developmental apoptosis in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.