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Article

Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor.

The EMBO journal - 15 Dec 2003

Rajpal Arvind, Cho Yuri A, Yelent Biana, Koza-Taylor Petra H, Li Dongling, Chen Elaine, Whang Michael, Kang Chulho, Turi Thomas G, Winoto Astar

Abstract excerpt

Nur77 is a nuclear orphan steroid receptor that has been implicated in negative selection. Expression of Nur77 in thymocytes and cell lines leads to apoptosis through a mechanism that remains unclear. In some cell lines, Nur77 was reported to act through a transcription-independent mechanism involving translocation to mitochondria, leading to cytochrome c release. However, we show here that Nur77-mediated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Receptors, Antigen, T-Cell

Share to Receptors, Cytoplasmic and Nuclear

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Source

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Identifiers

PMID: 14657025
DOI: 10.1093/emboj/cdg620
PMCID: PMC291815

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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