Article
Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor.
The EMBO journal - 15 Dec 2003
Rajpal Arvind, Cho Yuri A, Yelent Biana, Koza-Taylor Petra H, Li Dongling, Chen Elaine, Whang Michael, Kang Chulho, Turi Thomas G, Winoto Astar
Abstract excerpt
Nur77 is a nuclear orphan steroid receptor that has been implicated in negative selection. Expression of Nur77 in thymocytes and cell lines leads to apoptosis through a mechanism that remains unclear. In some cell lines, Nur77 was reported to act through a transcription-independent mechanism involving translocation to mitochondria, leading to cytochrome c release. However, we show here that Nur77-mediated...
Topics
- Amino Acid Sequence
- Animals
- Apoptosis
- Base Sequence
- Cells, Cultured
- Cloning, Molecular
- DNA Primers
- DNA-Binding Proteins
- Escherichia coli
- Female
- Genotype