Article
Characterization of a p75(NTR) apoptotic signaling pathway using a novel cellular model.
The Journal of biological chemistry - 7 Sept 2001
Wang X, Bauer J H, Li Y, Shao Z, Zetoune F S, Cattaneo E, Vincenz C
Abstract excerpt
The p75 neurotrophin receptor (p75(NTR)) belongs to the tumor necrosis factor receptor/nerve growth factor receptor superfamily. In some cells derived from neuronal tissues it causes cell death through a poorly characterized pathway. We developed a neuronal system using conditionally immortalized striatal neurons, in which the expression of p75(NTR) is inducibly controlled by the ecdysone receptor. In these cells...
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