Article
NRAGE, a p75NTR adaptor protein, is required for developmental apoptosis in vivo.
Cell death and differentiation - 1 Dec 2008
Bertrand M J M, Kenchappa R S, Andrieu D, Leclercq-Smekens M, Nguyen H N T, Carter B D, Muscatelli F, Barker P A, De Backer O
Abstract excerpt
NRAGE (also known as Maged1, Dlxin) is a member of the MAGE gene family that may play a role in the neuronal apoptosis that is regulated by the p75 neurotrophin receptor (p75NTR). To test this hypothesis in vivo, we generated NRAGE knockout mice and found that NRAGE deletion caused a defect in developmental apoptosis of sympathetic neurons of the superior cervical ganglia, similar to that observed in p75NTR...
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