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Article

Revising the mechanism of p75NTR activation: intrinsically monomeric state of death domains invokes the "helper" hypothesis.

Scientific reports - 13 Aug 2020

Goncharuk Sergey A, Artemieva Lilya E, Nadezhdin Kirill D, Arseniev Alexander S, Mineev Konstantin S

Abstract excerpt

The neurotrophin receptor p75NTR plays crucial roles in neuron development and regulates important neuronal processes like degeneration, apoptosis and cell survival. At the same time the detailed mechanism of signal transduction is unclear. One of the main hypotheses known as the snail-tong mechanism assumes that in the inactive state, the death domains interact with each other and in response to ligand binding...

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Identifiers

PMID: 32792564
DOI: 10.1038/s41598-020-70721-8
PMCID: PMC7427093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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