Article
Sample size requirements to control for stochastic variation in magnitude and location of allele-sharing linkage statistics in affected sibling pairs.
Annals of human genetics - 1 Sept 2001
Cordell H J
Abstract excerpt
Typically, genome scans for complex disease have produced linkage peaks which have proved difficult to replicate in additional independent studies. Here we confirm that this may be due to the large variance in magnitude and position of the linkage statistics when maximized across a region. Simulations suggest that for genes of moderate effect (locus-specific sibling relative risks lambda s in the range...
Topics
- Alleles
- Genetic Diseases, Inborn
- Genetic Linkage
- Humans
- Models, Genetic
- Nuclear Family
- Sample Size
- Statistics, Nonparametric
- Stochastic Processes