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Article

Prospects for association-based fine mapping of a susceptibility gene for a complex disease.

Theoretical population biology - 1 Nov 2001

Kaplan N, Morris R

Abstract excerpt

The potential of association studies for fine-mapping loci with common disease susceptibility alleles for complex genetic diseases in outbred populations is unclear. For a battery of tightly linked anonymous genetic markers spanning a candidate region centered around a disease locus, simulation methods based on a coalescent process with mutation, recombination, and genetic drift were used to study the spatial...

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PMID: 11855952
DOI: 10.1006/tpbi.2001.1537

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