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Article

Association mapping of complex diseases in linked regions: estimation of genetic effects and feasibility of testing rare variants.

Genetic epidemiology - 1 Jan 2003

Wang William Y S, Cordell Heather J, Todd John A

Abstract excerpt

Association mapping in linked regions is a current major approach for the identification of genes for complex diseases. Loci contributing to linkage, even with small values of sibling recurrence risk (lambda(s)), may be equivalent to substantial underlying genetic effects for association studies. For disease alleles with a frequency as low as 1%, highly reliable association studies (80% power for significance...

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PMID: 12508254
DOI: 10.1002/gepi.10216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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