Issues concerning association studies for fine mapping a susceptibility gene for a complex disease.

doi:10.1002/gepi.1012

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Article

Issues concerning association studies for fine mapping a susceptibility gene for a complex disease.

Genetic epidemiology - 1 May 2001

Kaplan N, Morris R

Abstract excerpt

The usefulness of association studies for fine mapping loci with common susceptibility alleles for complex genetic diseases in outbred populations is unclear. We investigate this issue for a battery of tightly linked anonymous genetic markers spanning a candidate region centered around a disease locus, and study the joint behavior of chi-square statistics used to discover and to localize the disease locus. We...

Topics

Case-Control Studies
Chi-Square Distribution
Chromosome Mapping
Gene Frequency
Genetic Markers
Genetic Predisposition to Disease
Haplotypes
Humans
Linkage Disequilibrium
Models, Genetic

Source

Open in PubMed

Identifiers

PMID: 11319784
DOI: 10.1002/gepi.1012

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