Linkage analysis of complex diseases using microsatellites and single-nucleotide polymorphisms: application to alcoholism.

doi:10.1186/1471-2156-6-S1-S10

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Article

Linkage analysis of complex diseases using microsatellites and single-nucleotide polymorphisms: application to alcoholism.

BMC genetics - 30 Dec 2005

Nsengimana Jérémie, Renard Hélène, Goldgar David

Abstract excerpt

The efficacy of linkage studies using microsatellites and single-nucleotide polymorphisms (SNPs) was evaluated. Analyzed data were supplied by the Collaborative Study on the Genetics of Alcoholism (COGA). Alcoholism was analyzed together with a simulated trait caused by a gene of known position, through a nonparametric linkage test (NPL). For the alcoholism trait, four densities of SNPs (1 SNP per 0.2 cM, 0.5 cM,...

Topics

Alcoholism
Computer Simulation
Genetic Linkage
Haplotypes
Humans
Microsatellite Repeats
Polymorphism, Single Nucleotide
Quantitative Trait, Heritable
Statistics, Nonparametric

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Identifiers

PMID: 16451555
DOI: 10.1186/1471-2156-6-S1-S10
PMCID: PMC1866840

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