Article
High-resolution genetic mapping of complex traits.
American journal of human genetics - 1 May 1995
Kruglyak L, Lander E S
Abstract excerpt
Positional cloning requires high-resolution genetic mapping. To plan a positional cloning project, one needs to know how many informative meioses will be required to narrow the search for a disease gene to an acceptably small region. For a simple Mendelian trait studied with linkage analysis, the answer is straightforward. In this paper, we address the situation of a complex trait studied with...
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