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Article

Design Considerations for Genetic Linkage and Association Studies.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017

Nsengimana Jérémie, Bishop D Timothy

Abstract excerpt

This chapter describes the main issues that genetic epidemiologists usually consider in the design of linkage and association studies. For linkage, we briefly consider the situation of rare highly penetrant alleles showing a disease pattern consistent with Mendelian inheritance investigated through parametric methods in large pedigrees, or with autozygosity mapping in inbred families, and we then turn our focus...

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PMID: 28980250
DOI: 10.1007/978-1-4939-7274-6_13

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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