Article
Finding genes underlying risk of complex disease by linkage disequilibrium mapping.
Current opinion in genetics & development - 1 Jun 2003
Clark Andrew G
Abstract excerpt
Identification of genes that harbor variation associated with inter-individual differences in risk of complex diseases remains one of the most challenging and important problems in human genetics. For genetic variants that are sufficiently common and have sufficiently large effects, direct tests of association through linkage disequilibrium with anonymous SNPs may prove effective. But the two critical parameters...
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