Detecting linkage for a complex disease using simulated extended pedigrees.

doi:10.1002/(SICI)1098-2272(1997)14:6<981::AID-GEPI70>3.0.CO;2-G

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Article

Detecting linkage for a complex disease using simulated extended pedigrees.

Genetic epidemiology - 1 Jan 1997

DeStefano A L, Cupples L A, Myers R H, Farrer L A

Abstract excerpt

The simulated extended pedigree data of the Genetic Analysis Workshop 10 were used to examine the relationship between several quantitative traits (Q1-Q5), an environmental factor, age and sex and to identify genes contributing to the quantitative traits. A forward selection procedure was used to...

Topics

Age Distribution
Chromosome Mapping
Computer Simulation
Environment
Female
Genetic Diseases, Inborn
Genetic Linkage
Genetic Testing
Genome, Human
Genotype
Humans
Male
Matched-Pair Analysis
Pedigree
Quantitative Trait, Heritable
Regression Analysis

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