Article
A comparison of different linkage statistics in small to moderate sized pedigrees with complex diseases.
BMC research notes - 6 Aug 2012
Flaquer Antònia, Strauch Konstantin
Abstract excerpt
BACKGROUND: In the last years GWA studies have successfully identified common SNPs associated with complex diseases. However, most of the variants found this way account for only a small portion of the trait variance. This fact leads researchers to focus on rare-variant mapping with large scale sequencing, which can be facilitated by using linkage information. The question arises why linkage analysis often fails...
Topics
- Chromosome Mapping
- Computer Simulation
- Genes, Dominant
- Genes, Recessive
- Genetic Linkage
- Genome-Wide Association Study
- Humans
- Inheritance Patterns
- Models, Genetic
- Pedigree
- Phenotype