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Article

A comparison of different linkage statistics in small to moderate sized pedigrees with complex diseases.

BMC research notes - 6 Aug 2012

Flaquer Antònia, Strauch Konstantin

Abstract excerpt

BACKGROUND: In the last years GWA studies have successfully identified common SNPs associated with complex diseases. However, most of the variants found this way account for only a small portion of the trait variance. This fact leads researchers to focus on rare-variant mapping with large scale sequencing, which can be facilitated by using linkage information. The question arises why linkage analysis often fails...

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Source

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Identifiers

PMID: 22862841
DOI: 10.1186/1756-0500-5-411
PMCID: PMC3475142

Genes

NPL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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