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Article

Glycemic control in mice with targeted disruption of the glucagon receptor gene.

Biochemical and biophysical research communications - 18 Jan 2002

Parker Janice C, Andrews Kim M, Allen Melanie R, Stock Jeffrey L, McNeish John D

Abstract excerpt

The action of glucagon in the liver is mediated by G-coupled receptors. To examine the role of glucagon in glucose homeostasis, we have generated mice in which the glucagon receptor was inactivated (GR(-/-) mice). Blood glucose levels were somewhat reduced in GR(-/-) mice relative to wild type, in both the fed and fasted state. Plasma insulin levels were not significantly affected. There was no significant effect...

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Source

Identifiers

PMID: 11785978
DOI: 10.1006/bbrc.2001.6265

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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