Article
Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice.
Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 2003
Gelling R W, Du X Q, Dichmann D S, Romer J, Huang H, Cui L, Obici S, Tang B, Holst J J, Fledelius C, Johansen P B, Rossetti L, Jelicks L A, Serup P, Nishimura E, Charron M J
Abstract excerpt
Glucagon, the counter-regulatory hormone to insulin, is secreted from pancreatic alpha cells in response to low blood glucose. To examine the role of glucagon in glucose homeostasis, mice were generated with a null mutation of the glucagon receptor (Gcgr(-/-)). These mice display lower blood glucose levels throughout the day and improved glucose tolerance but similar insulin levels compared with control animals....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.