Article
Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice.
Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 2003
Gelling R W, Du X Q, Dichmann D S, Romer J, Huang H, Cui L, Obici S, Tang B, Holst J J, Fledelius C, Johansen P B, Rossetti L, Jelicks L A, Serup P, Nishimura E, Charron M J
Abstract excerpt
Glucagon, the counter-regulatory hormone to insulin, is secreted from pancreatic alpha cells in response to low blood glucose. To examine the role of glucagon in glucose homeostasis, mice were generated with a null mutation of the glucagon receptor (Gcgr(-/-)). These mice display lower blood glucose levels throughout the day and improved glucose tolerance but similar insulin levels compared with control animals....
Topics
- Animals
- Blood Glucose
- Body Weight
- Calorimetry
- Cell Division
- Cyclic AMP
- Epididymis
- Epinephrine
- Glucagon
- Glucose