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Article

Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis.

The Journal of clinical investigation - 1 May 2011

Ali Safina, Lamont Benjamin J, Charron Maureen J, Drucker Daniel J

Abstract excerpt

Disordered glucagon secretion contributes to the symptoms of diabetes, and reduced glucagon action is known to improve glucose homeostasis. In mice, genetic deletion of the glucagon receptor (Gcgr) results in increased levels of the insulinotropic hormone glucagon-like peptide 1 (GLP-1), which may contribute to the alterations in glucose homeostasis observed in Gcgr-/- mice. Here, we assessed the contribution of...

Topics

Animals
Cholecystokinin
Glucagon
Glucagon-Like Peptide-1 Receptor
Glucose Tolerance Test
Incretins
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Oxygen Consumption

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pancreas

Phenotype

Rats

Receptors, Glucagon

Source

Open in PubMed Open full text

Identifiers

PMID: 21540554
DOI: 10.1172/JCI43615
PMCID: PMC3083792

Genes

GIP
CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis.PMID 21540554Read ↗

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