Article
Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation.
Endocrinology - 1 Sept 2006
Vuguin Patricia M, Kedees Mamdouh H, Cui Lingguang, Guz Yelena, Gelling Richard W, Nejathaim Morris, Charron Maureen J, Teitelman Gladys
Abstract excerpt
Although glucagon (GLU) plays a pivotal role in glucose homeostasis, its role in the regulation of fetal growth and maturation is poorly understood. These issues were examined in a line of mice with a global deletion of the GLU receptor (Gcgr-/-), which are characterized by lower blood glucose levels and by alpha- and delta-cell hyperplasia in adults. Ablation of Gcgr was deleterious to fetal survival; it delayed...
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