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Article

Glucagon receptor inactivation leads to α-cell hyperplasia in zebrafish

1 Nov 2015

Abstract excerpt

Glucagon antagonism is a potential treatment for diabetes. One potential side effect is α-cell hyperplasia, which has been noted in several approaches to antagonize glucagon action. To investigate the molecular mechanism of the α-cell hyperplasia and to identify the responsible factor, we created a zebrafish model in which glucagon receptor (gcgr) signaling has been interrupted. The genetically and chemically...

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PMID: 26446275
DOI: 10.1530/joe-15-0284

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Glucagon receptor inactivation leads to α-cell hyperplasia in zebrafishPMID 26446275Read ↗

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