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Article

Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus.

Molecular endocrinology (Baltimore, Md.) - 1 Jun 2004

Opherk Christian, Tronche François, Kellendonk Christoph, Kohlmüller Dirk, Schulze Andreas, Schmid Wolfgang, Schütz Günther

Abstract excerpt

Hepatic glucose production by gluconeogenesis is the main source of glucose during fasting and contributes significantly to hyperglycemia in diabetes mellitus. Accordingly, glucose metabolism is tightly controlled by a variety of hormones including insulin, epinephrine, glucagon, and glucocortico...

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Source

Identifiers

PMID: 15031319
DOI: 10.1210/me.2003-0283

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15031319-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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