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Deleterious mutation V369M in the mouse GCGR gene causes abnormal plasma amino acid levels indicative of a possible liver-α-cell axis.

Bioscience reports - 25 Jun 2021

Liu Qiaofeng, Lin Guangyao, Chen Yan, Feng Wenbo, Xu Yingna, Lyu Jianjun, Yang Dehua, Wang Ming-Wei

Abstract excerpt

Glucagon plays an important role in glucose homeostasis and amino acid metabolism. It regulates plasma amino acid levels which in turn modulate glucagon secretion from the pancreatic α-cell, thereby establishing a liver-α-cell axis described recently. We reported previously that the knock-in mice bearing homozygous V369M substitution (equivalent to a naturally occurring mutation V368M in the human glucagon...

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Identifiers

PMID: 34002801
DOI: 10.1042/BSR20210758
PMCID: PMC8173527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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