Article
Characterization of a naturally occurring mutation V368M in the human glucagon receptor and its association with metabolic disorders.
The Biochemical journal - 17 Jul 2020
Lin Guangyao, Liu Qiaofeng, Dai Antao, Cai Xiaoqing, Zhou Qingtong, Wang Xi, Chen Yan, Ye Chenyu, Li Jie, Yang Dehua, Wang Ming-Wei
Abstract excerpt
Glucagon is a peptide hormone secreted by islet α cells. It plays crucial roles in glucose homeostasis and metabolism by activating its cognate glucagon receptor (GCGR). A naturally occurring deleterious mutation V368M in the human GCGR leads to reduced ligand binding and down-regulation of glucagon signaling. To examine the association between this mutation and metabolic disorders, a knock-in mouse model bearing...
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