Article
Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele.
The American journal of physiology - 1 Oct 1997
Rossetti L, Chen W, Hu M, Hawkins M, Barzilai N, Efrat S
Abstract excerpt
Glucokinase (GK) catalyzes the phosphorylation of glucose in beta-cells and hepatocytes, and mutations in the GK gene have been implicated in a form of human diabetes. To investigate the relative role of partial deficiencies in the hepatic vs. pancreatic GK activity, we examined insulin secretion...
Topics
- Alleles
- Animals
- Blood Glucose
- Glucokinase
- Glucose
- Humans
- Hyperglycemia
- Insulin
- Islets of Langerhans
- Liver
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
- Uridine Diphosphate Glucose