Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele.

The American journal of physiology - 1 Oct 1997

Rossetti L, Chen W, Hu M, Hawkins M, Barzilai N, Efrat S

Abstract excerpt

Glucokinase (GK) catalyzes the phosphorylation of glucose in beta-cells and hepatocytes, and mutations in the GK gene have been implicated in a form of human diabetes. To investigate the relative role of partial deficiencies in the hepatic vs. pancreatic GK activity, we examined insulin secretion, glucose disposal, and hepatic glucose production (HGP) in response to hyperglycemia in transgenic mice 1) with one...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Glucose
Share to Insulin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mice, Knockout

Share to Mice, Transgenic

Source

Identifiers

PMID: 9357804
DOI: 10.1152/ajpendo.1997.273.4.E743

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele.PMID 9357804Read ↗

Cell-specific roles of glucokinase in glucose homeostasis.Semantic proximity Read ↗

Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis.Semantic proximity Read ↗

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase.Semantic proximity Read ↗

Sex-dependent additive effects of dorzagliatin and incretin on insulin secretion in a novel mouse model of <i>GCK</i> -MODYSemantic proximity Read ↗

Glucokinase activity suppresses hepatic cholesterol synthesis and triglyceride accumulation: A new model for the effects of the GKRP P466L common human variantSemantic proximity Read ↗

Abnormal regulation of hepatic glucose output in maturity-onset diabetes of the young caused by a specific mutation of the glucokinase gene.Semantic proximity Read ↗

ATP-sensitive K+ channel signaling in glucokinase-deficient diabetes.Semantic proximity Read ↗

G6PC2 confers protection against hypoglycemia upon ketogenic diet feeding and prolonged fasting.Semantic proximity Read ↗

Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene.Semantic proximity Read ↗

Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations.Semantic proximity Read ↗

[Role of glucokinase (GK) in the maintenance of glucose homeostasis. Specific disruption of the gene by the Cre-loxP technique].Semantic proximity Read ↗

Adaptation to hyperglycemia enhances insulin secretion in glucokinase mutant mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.