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Article

Islet function phenotype in gastrin-releasing peptide receptor gene-deficient mice.

Endocrinology - 1 Oct 2002

Persson Kristin, Pacini Giovanni, Sundler Frank, Ahrén Bo

Abstract excerpt

Gastrin-releasing peptide (GRP) is an islet neuropeptide that stimulates insulin secretion. To explore whether islet GRP contributes to neurally mediated insulin secretion, we studied GRP receptor (GRPR)-deleted mice. By using RT-PCR we showed that GRPR mRNA is expressed in islets of wild-type mice, but is lost in GRPR-deleted mice. Functional studies revealed that GRP potentiates glucose-stimulated insulin...

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Source

Identifiers

PMID: 12239081
DOI: 10.1210/en.2002-220371

Genes

GRPR
GRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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