Article
Absence of the glucagon-like peptide-1 receptor does not affect the metabolic phenotype of mice with liver-specific G(s)α deficiency.
Endocrinology - 1 Sept 2011
Chen Min, Mema Eralda, Kelleher James, Nemechek Nicholas, Berger Alta, Wang Jie, Xie Tao, Gavrilova Oksana, Drucker Daniel J, Weinstein Lee S
Abstract excerpt
The stimulatory G protein α-subunit (G(s)α) couples hormone and other receptors to the generation of intracellular cAMP. We previously showed that mice with liver-specific G(s)α deficiency [liver-specific G(s)α knockout (LGsKO) mice] had reduced adiposity and improved glucose tolerance associated with increased glucose-stimulated insulin secretion, pancreatic islet hyperplasia, and very high serum glucagon and...
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