Article
Identification of glucagon-like peptide 1 (GLP-1) actions essential for glucose homeostasis in mice with disruption of GLP-1 receptor signaling.
Diabetes - 1 Apr 1998
Scrocchi L A, Marshall B A, Cook S M, Brubaker P L, Drucker D J
Abstract excerpt
Glucagon-like peptide-1 (GLP-1) acts to control blood glucose via multiple mechanisms, including regulation of insulin and glucagon secretion, gastric emptying, satiety, and peripheral insulin sensitivity. However, the relative importance of these actions for regulation of blood glucose remains unclear. We demonstrate here a gene dosage effect for the incretin action of GLP-1, as heterozygous GLP-1R +/- mice...
Topics
- Alleles
- Animals
- Blood Glucose
- Female
- Glucagon
- Glucagon-Like Peptide 1
- Glucagon-Like Peptide-1 Receptor
- Glucose Tolerance Test
- Homeostasis
- Insulin
- Intestinal Mucosa
- Male
- Mice
- Mutation