Article
Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice.
Proceedings of the National Academy of Sciences of the United States of America - 7 Mar 2017
Okamoto Haruka, Cavino Katie, Na Erqian, Krumm Elizabeth, Kim Sun Y, Cheng Xiping, Murphy Andrew J, Yancopoulos George D, Gromada Jesper
Abstract excerpt
Inactivating mutations in the insulin receptor results in extreme insulin resistance. The resulting hyperglycemia is very difficult to treat, and patients are at risk for early morbidity and mortality from complications of diabetes. We used the insulin receptor antagonist S961 to induce severe insulin resistance, hyperglycemia, and ketonemia in mice. Using this model, we show that glucagon receptor (GCGR)...
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