Article
Loss of critical palindromic transgene promoter sequence in chemically induced Tg.AC mouse skin papillomas expressing transgene-derived mRNA.
Molecular carcinogenesis - 1 Dec 2001
Thompson K L, Rosenzweig B A, Honchel R, Cannon R E, Blanchard K T, Stoll R E, Sistare F D
Abstract excerpt
The Tg.AC transgenic mouse carries a v-Ha-ras transgene. Skin papillomas develop in Tg.AC mice upon repeated dermal application of tumor promoters and carcinogens. The transgene is inserted at a single site on chromosome 11 in a multiple-copy array. Although most of the >or= 40 copies are arranged in a direct-repeat orientation, two copies of the transgene are inserted in a palindromic, inverted-repeat...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.