Article
An evaluation of the hemizygous transgenic Tg.AC mouse for carcinogenicity testing of pharmaceuticals. II. A genotypic marker that predicts tumorigenic responsiveness.
Toxicologic pathology - 1 Jan 2000
Thompson K L, Rosenzweig B A, Sistare F D
Abstract excerpt
The Tg.AC transgenic mouse skin paint assay is one of the short-term carcinogenesis models that has been proposed as a replacement for 1 species in the conventional 2-yr bioassay required for safety testing of pharmaceuticals. In our initial efforts to evaluate the sensitivity and specificity of...
Topics
- Administration, Topical
- Animals
- Biomarkers, Tumor
- Blotting, Southern
- Carcinogenicity Tests
- Carcinogens
- Genetic Markers
- Genotype
- Mice
- Mice, Transgenic
- Papilloma
- Skin Neoplasms
- Transgenes
- Weight Gain