Article
Decreases in phorbol ester-induced papilloma development in v-Ha-ras transgenic TG.AC mice during reduced gene dosage of bcl-2.
Molecular carcinogenesis - 1 Sept 1997
Trempus C S, Haseman J K, Tennant R W
Abstract excerpt
We have demonstrated that induction of transgene expression in the v-Ha-ras-transgenic TG.AC mouse is a critical event in skin tumorigenesis and that cutaneous papillomas arise from follicular epidermis after treatment with chemical carcinogens. The sensitivity of TG.AC mice to skin tumorigenesis...
Topics
- Animals
- Carcinogens
- Cocarcinogenesis
- Female
- Gene Expression
- Gene Transfer Techniques
- Genes, bcl-2
- Genes, ras
- Genotype
- Male
- Mice
- Mice, Transgenic
- Papilloma
- Proto-Oncogene Proteins c-bcl-2
- Skin Neoplasms
- Tetradecanoylphorbol Acetate