Article
Rapid induction of skin and mammary tumors in human c-Ha-ras proto-oncogene transgenic rats by treatment with 7,12-dimethylbenz[a]anthracene followed by 12-O-tetradecanoylphorbol 13-acetate.
Cancer science - 1 Mar 2004
Park Cheol Beom, Fukamachi Katsumi, Takasuka Nobuo, Han Beom Seok, Kim Chuel Kyu, Hamaguchi Tetsuya, Fujita Ken-ichi, Ueda Shinobu, Tsuda Hiroyuki
Abstract excerpt
We have established a transgenic rat line carrying 3 copies of the human c-Ha-ras proto-oncogene with its own promoter region (Jcl/SD-TgN(HrasGen)128Ncc) (Hras128 rat), expression being detectable in almost all organs. We have already demonstrated that the rat is highly sensitive to mammary, esophagus and bladder carcinogenesis. In the present study, male and female transgenic and wild-type littermates were...
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