Article
Photocarcinogenesis and susceptibility to UV radiation in the v-Ha-ras transgenic Tg.AC mouse.
The Journal of investigative dermatology - 1 Sept 1998
Trempus C S, Mahler J F, Ananthaswamy H N, Loughlin S M, French J E, Tennant R W
Abstract excerpt
The v-Ha-ras transgenic Tg.AC mouse line has proven to be a useful model for the study of chemical carcinogenic potential. We undertook experiments designed to study the effect of the physical carcinogen, UV radiation, on tumorigenesis in this mouse strain. Following a total of three exposures on alternating days to a radiation source covering a cumulative UVR exposure range of 2.6-42.6 kJ per m2, squamous...
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