SENCAR mouse skin tumors produced by promotion alone have A to G mutations in codon 61 of the c-rasHa gene.

doi:10.1093/carcin/15.9.1975

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Article

SENCAR mouse skin tumors produced by promotion alone have A to G mutations in codon 61 of the c-rasHa gene.

Carcinogenesis - 1 Sept 1994

Sutter C, Greenhalgh D A, Ueda M, Abhyankar S, Ngai P, Hennings H, Schweizer J, Yuspa S H, Strickland J E

Abstract excerpt

SENCAR mice, developed by selective breeding for high susceptibility to skin carcinogenesis by initiation with 7,12-dimethylbenz[a]anthracene and promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA), form squamous papillomas in approximately 20% of animals treated repeatedly with TPA, without chemical initiation. DNA from eight skin tumors produced by a TPA-only protocol and four cell lines derived from...

Topics

9,10-Dimethyl-1,2-benzanthracene
Adenine
Animals
Base Sequence
Cocarcinogenesis
Codon
Cytosine
DNA, Neoplasm
Exons
Female
Genes, ras

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred SENCAR

Mice, Nude

Molecular Sequence Data

Mutation

Nucleic Acid Hybridization

Papilloma

Source

Open in PubMed

Identifiers

PMID: 7522983
DOI: 10.1093/carcin/15.9.1975

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7522983-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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SENCAR mouse skin tumors produced by promotion alone have A to G mutations in codon 61 of the c-rasHa gene.PMID 7522983Read ↗

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Both (+/-)syn- and (+/-)anti-7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxides initiate tumors in mouse skin that possess -CAA- to -CTA- mutations at Codon 61 of c-H-ras.Semantic proximity Read ↗

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