Article
Chemically induced forestomach papillomas in transgenic mice carry mutant human c-Ha-ras transgenes.
Cancer research - 15 Feb 1992
Ando K, Saitoh A, Hino O, Takahashi R, Kimura M, Katsuki M
Abstract excerpt
Forestomach papillomas and skin papillomas were induced very efficiently by a single dose administration of the chemical carcinogen methylnitrosourea (MNU) in transgenic mice (rasH2 line) carrying human hybrid c-Ha-ras genes, which encode the prototype p21 gene product. The incidence of forestomach papillomas was dose dependent; when 50 mg/kg of MNU were administered i.p., all of the transgenic mice (56 of 56)...
Topics
- Animals
- Base Sequence
- Dose-Response Relationship, Drug
- Gene Expression
- Genes, ras
- Humans
- Lymphoma
- Methylnitrosourea
- Mice
- Mice, Transgenic
- Molecular Sequence Data