Methylation of the O6-methylguanine-DNA methyltransferase promoter suppresses expression in mouse skin tumors and varies with the tumor induction protocol.

doi:10.1002/ijc.21316

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Article

Methylation of the O6-methylguanine-DNA methyltransferase promoter suppresses expression in mouse skin tumors and varies with the tumor induction protocol.

International journal of cancer - 1 Feb 2006

Abdel-Fattah Rana, Glick Adam, Rehman Ishtiaq, Maiberger Patrick, Hennings Henry

Abstract excerpt

Hypermethylation of CpG sites within the promoter region of the O6-methylguanine-DNA methyltransferase (MGMT) gene occurs frequently in human cancer, preventing both MGMT expression and repair of alkylation damage. To assess the role of MGMT in the development of mouse skin tumors induced by initiation-promotion protocols, methylation of the MGMT promoter was examined in tumor DNA using methylation-specific PCR....

Topics

9,10-Dimethyl-1,2-benzanthracene
Animals
Carcinogens
Carcinoma, Squamous Cell
DNA Methylation
Diterpenes
Gene Expression Regulation, Neoplastic
Genes, ras
Humans
Methylnitronitrosoguanidine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

O(6)-Methylguanine-DNA Methyltransferase

Papilloma

Promoter Regions, Genetic

Skin

Skin Neoplasms

Tetradecanoylphorbol Acetate

Source

Open in PubMed

Identifiers

PMID: 16094607
DOI: 10.1002/ijc.21316

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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