Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic interaction between the unstable v-Ha-RAS transgene (Tg.AC) and the murine Werner syndrome gene: transgene instability and tumorigenesis.

Oncogene - 26 Sept 2002

Leder Aya, Lebel Michel, Zhou Fen, Fontaine Karen, Bishop Alexander, Leder Philip

Abstract excerpt

Tg.AC transgenic mice provide a sensitive assay for oncogenic agents and a convenient alternative to the two-stage initiation/promoter model of skin tumorigenesis. Although extensively used, this model has remained in part an enigma since mice that carry the Tg.AC transgene (consisting of v-Ha-Ras driven by an embryonic zeta-globin promoter) would not ordinarily be expected to develop skin and other adult tumors....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Helicases
Share to Exodeoxyribonucleases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Papilloma

Share to RecQ Helicases

Share to Tetradecanoylphorbol Acetate

Share to Transgenes

Share to Werner Syndrome

Share to Werner Syndrome Helicase

Source

Identifiers

PMID: 12242664
DOI: 10.1038/sj.onc.1205795

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic interaction between the unstable v-Ha-RAS transgene (Tg.AC) and the murine Werner syndrome gene: transgene instability and tumorigenesis.PMID 12242664Read ↗

Genome-wide SNP analysis of Tg.AC transgenic mice reveals an oncogenic collaboration between v-Ha-ras and Ink4a, which is absent in p53 deficiency.Semantic proximity Read ↗

Loss of critical palindromic transgene promoter sequence in chemically induced Tg.AC mouse skin papillomas expressing transgene-derived mRNA.Semantic proximity Read ↗

Loss of palindromic symmetry in Tg.AC mice with a nonresponder phenotype.Semantic proximity Read ↗

Photocarcinogenesis and susceptibility to UV radiation in the v-Ha-ras transgenic Tg.AC mouse.Semantic proximity Read ↗

Transgenic coexpression of v-Ha-ras and transforming growth factor alpha increases epidermal hyperproliferation and tumorigenesis and predisposes to malignant conversion via endogenous c-Ha-ras activation.Semantic proximity Read ↗

TGF alpha is dispensable for skin tumorigenesis in Tg.AC mice.Semantic proximity Read ↗

Tumor spectrum in the p53 heterozygous zeta globin-promoted Tg.AC (v-Ha-ras) bitransgenic mouse model.Semantic proximity Read ↗

An evaluation of the hemizygous transgenic Tg.AC mouse for carcinogenicity testing of pharmaceuticals. II. A genotypic marker that predicts tumorigenic responsiveness.Semantic proximity Read ↗

Altered telomere homeostasis and resistance to skin carcinogenesis in Suv39h1 transgenic mice.Semantic proximity Read ↗

Decreases in phorbol ester-induced papilloma development in v-Ha-ras transgenic TG.AC mice during reduced gene dosage of bcl-2.Semantic proximity Read ↗

Autocrine transforming growth factor alpha is dispensible for v-rasHa-induced epidermal neoplasia: potential involvement of alternate epidermal growth factor receptor ligands.Semantic proximity Read ↗

Most tumors in transgenic mice with human c-Ha-ras gene contained somatically activated transgenes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.