Article
Abnormalities of epidermal differentiation associated with expression of the human papillomavirus type 1 early region in transgenic mice.
The Journal of general virology - 1 May 1992
Tinsley J M, Fisher C, Searle P F
Abstract excerpt
The promoter region of a keratin 6 (K6) gene was used to regulate expression of the early region of human papillomavirus type 1 (HPV-1e) in transgenic mice. In one line of mice the K6-HPV1e transgene was transcribed in several regions of the skin, the predominant transcript being a 1.1 kb RNA including the E4 open reading frame, and E1-E4 protein was detected in the upper suprabasal layers of the skin in paws and...
Topics
- Animals
- Base Sequence
- DNA, Recombinant
- Epidermis
- Extremities
- Genes, Viral
- Keratins
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Oncogene Proteins, Viral