Article
TGF alpha is dispensable for skin tumorigenesis in Tg.AC mice.
Toxicologic pathology - 1 Jan 2000
Humble M C, Szczesniak C J, Luetteke N C, Spalding J W, Cannon R E, Hansen L A, Lee D C, Tennant R W
Abstract excerpt
Alterations in growth factor signaling pathways frequently accompany the development and maintenance of epithelial neoplasia. Transforming growth factor alpha (TGF alpha) and its epidermal growth factor receptor have been thought to play an especially important role in epithelial neoplasia. In th...
Topics
- Animals
- Carcinogens
- Carcinoma
- Carcinoma, Squamous Cell
- ErbB Receptors
- Female
- Genotype
- Mice
- Mice, Transgenic
- Papilloma
- Rats
- Reverse Transcriptase Polymerase Chain Reaction
- Skin Neoplasms
- Transforming Growth Factor alpha
- Wound Healing