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Article

TGF alpha is dispensable for skin tumorigenesis in Tg.AC mice.

Toxicologic pathology - 1 Jan 2000

Humble M C, Szczesniak C J, Luetteke N C, Spalding J W, Cannon R E, Hansen L A, Lee D C, Tennant R W

Abstract excerpt

Alterations in growth factor signaling pathways frequently accompany the development and maintenance of epithelial neoplasia. Transforming growth factor alpha (TGF alpha) and its epidermal growth factor receptor have been thought to play an especially important role in epithelial neoplasia. In this study, mice were derived genetically deficient (null) in functional TGF alpha expression and carrying the...

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PMID: 9715516
DOI: 10.1177/019262339802600413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TGF alpha is dispensable for skin tumorigenesis in Tg.AC mice.PMID 9715516Read ↗

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