Article
Regulation of adenylyl cyclases by a region outside the minimally functional cytoplasmic domains.
The Journal of biological chemistry - 11 Jan 2002
Parent Carole A, Borleis Jane, Devreotes Peter N
Abstract excerpt
The highly conserved topological structure of G protein-activated adenylyl cyclases seems unnecessary because the soluble cytoplasmic domains retain regulatory and catalytic properties. Yet, we previously isolated a constitutively active mutant of the Dictyostelium discoideum adenylyl cyclase harboring a single point mutation in the region linking the cytoplasmic and membrane domains (Leu-394). We show here that...
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