Article

Adenylyl cyclase 9 as a molecular scaffold to dissect the regulatory mechanisms of membrane adenylyl cyclases

2026-04-19

Abstract excerpt

<h4>ABSTRACT</h4> Adenylyl cyclases (ACs) convert ATP into the second messenger cAMP, thus directly influencing cellular signaling in response to a wide variety of stimuli. Despite their physiological importance, structural studies of isoform-specific AC regulation are compounded by difficulties in AC expression and purification. Here, we designed a chimeric construct AC95, combining human AC9 as a molecular scaf...

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Literature Corpus work: 1f7b7420-d6a9-54c4-a225-8148f647d695
DOI: 10.64898/2026.04.18.719376

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