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Article

Human adenylyl cyclase 9 is auto-stimulated by its isoform-specific C-terminal domain.

Life science alliance - 1 Apr 2023

Chen Zhihao, Antoni Ferenc A

Abstract excerpt

Human transmembrane adenylyl cyclase 9 (AC9) is not regulated by heterotrimeric G proteins. Key to the resistance to stimulation by Gs-coupled receptors (GsRs) is auto-inhibition by the COOH-terminal domain (C2b). The present study investigated the role of the C2b domain in the regulation of cyclic AMP production by AC9 in HEK293FT cells expressing the GloSensor22F cyclic AMP-reporter protein. Surprisingly, we...

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PMID: 36657828
DOI: 10.26508/lsa.202201791
PMCID: PMC9873982

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