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Article

Constitutively active G protein-coupled receptor mutants block dictyostelium development.

Molecular biology of the cell - 1 Feb 2005

Zhang Minghang, Goswami Mousumi, Hereld Dale

Abstract excerpt

cAR1, a G protein-coupled receptor (GPCR) for cAMP, is required for the multicellular development of Dictyostelium. The activation of multiple pathways by cAR1 is transient because of poorly defined adaptation mechanisms. To investigate this, we used a genetic screen for impaired development to isolate four dominant-negative cAR1 mutants, designated DN1-4. The mutant receptors inhibit multiple cAR1-mediated...

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Identifiers

PMID: 15574880
DOI: 10.1091/mbc.e04-06-0456
PMCID: PMC545893

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Source receipt: pubmed, retrieved 7 Sept 2026.

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