Article
Constitutively active adenylyl cyclase mutant requires neither G proteins nor cytosolic regulators.
The Journal of biological chemistry - 2 Aug 1996
Parent C A, Devreotes P N
Abstract excerpt
Receptor-mediated G protein-linked adenylyl cyclase systems are universal signal transducers. We exploited the essential role of this cascade in Dictyostelium development to screen for random mutations in the catalytic component, ACA. This enzyme is activated by G protein betagamma-subunits actin...
Topics
- Adenylyl Cyclases
- Amino Acid Sequence
- Animals
- Cytosol
- Dictyostelium
- Fungal Proteins
- GTP-Binding Proteins
- Kinetics
- Mammals
- Molecular Sequence Data
- Phenotype
- Point Mutation
- Protozoan Proteins